Bolt, I'd like to you to consider a couple things before you make this purchase.
First, do you buy shoes for your wife? Of course not. If you did it would be all wrong! Shoes like firearms are a personal, very personal, decision and fit and style of shoes is just as important as fit and style (caliber) of a handgun. The reason many women cannot manipulate a handgun is because the handgun does not fit them and also because they use "this gun my husband bought for me" as an excuse to fail. I don't pretrend to know a lot about women but most women want to make their own choices and decision when it comes to saving their own life or the life of their children. They just want us men to guide them and support them but not influance them and most certainly not buy a gun for them.
I'd suggest, strongly suggest, you and your wife attend together at least one and better is two defensive small arms training classes together with a highly competent professional who has rental guns. Let her learn the proper and effective manual of arms with both a revolver and a semi-auto. Then after this training she will have more competence and CONFIDENCE and will have the neccessary information and skill to select her OWN personal defensive handgun in the caliber of her own choosing.
I also suggest you go to a website and buy both of Vicki Farnam's books on teaching women to shoot defensively. I've attended Vicki's course several times for men who work with women students and I can tell you it has changed my channel on training women in the defensive arts.
Les and others...the reason many women struggle with reciprocating a slide and/or locking it to the rear is because of an ineffective technique. Unfortunately many ranges, range officers, and even instructors fail to understand there are at least two variations for women to be able to effectively to rack and/or lock open any defensive semi-auto. These techniques are not widely known or taught but are extremely effective in helping women who struggle in becoming successful. And once mastered women, even petite women, can do these tasks with ease.
Now, Bolt, keep this in mind. Every state has a Police Training Academy. Approximately every 16 weeks a new class of student/cadets show up for training. Amongst these cadets are women - many who have never touched, seen, or even operated any firearm much less a defensive handgun. Many of these women are a size 2. And yet, they are issued a 9mm, 40, or .45 generally in a full size. They are not told "now this is too much gun for you"...and instead are told "at the completion of your training you'll be able to successfully qualify with this duty pistol and you'll have the confidence to defend yourself against a violent armed encounter." Women, even those fresh out of college and from the big city where guns are not common are successful with full size duty guns. They do not have the option to use a 6 shot .22LR revolver.
It is time to displace this conventional wisdom which is unfortunately so prevelant amongst men that women are weak, helpless, and incapable of shooting a compact, or even sub compact semi or revolver of a larger caliber and they must be relegated to the cute, petite, little .38 snub nose or .22LR revolver. I've seen people with major finger, hand, arm disablities shoot 9s, 40s, and 45s to success -the reason because the gun fit their hand, and because someone didn't whisper into their ear "this gun is too much for you."
Finally, Bolt I need to challenge your assumption "No one wants to be shot." While this is rationale and true for those of us who are not Violent Criminal Actors (VCA). VCAs are wired and programmed differently than us. Many are so highly motivated the fear of being shot or challenged by someone with a handgun is not a major concern for them. A handgun, any handgun is a poor fight stopper. And many VCA's have been shot with .22LR rifles (one in my local area) and after multiple hits continue to press the attack or leave and go home to tend to their wounds only to live and kill another day.
We know from many police and home owner actual cases what is most often required to stop a motivated VCA is a committed, dedicated trained person who can operate under stress and shoot the vital organs up the mid-line and do so multiple times in rapid succession and be prepared to execute a combat reload and continue. We carry handguns because they small, compact and convient and not because their effective. So shooting multiple rounds is a common practice - unfortunately.
Honestly if she is this timid, then you ought to seriously consider sending her to an Oleoresin Capsicum course (OC/Pepper Spray) and arm her with FOX OC and some Suedicon wipes. Or you could also have her invest in a C-2 Taser which is effective. Both OC and the Taser are going to be at least equal and most likely more effective than a .22LR handgun - especially if she isn't committed in training. And when I say "training" I'm not implying "just target shooting or breaking clay pigeons at a rock pit" - I'm implying real defensive handgun training we she is learning how to defend herself besides learn how to shoot.
This mindset of men who believe women are so helpless and incapable of managing something larger than a .22LR is just not reality. The reality is women are tougher than we give them credit for and if we assist them rather than "doing or buying for them" and we give them the skills and knowledge they need to make sensible realistic decisions then you'll find they'll generally make a better choice than we would for them. Don't ask me how I know this - but I do!