I'm going to disagree with Sam a bit here. The heat treatment for all 3 steels involved here is to heat to 1500-1525F before quench in a fast oil. The difference is that 52100 likes more soak time at temperature. No problem, that won't negatively affect the 1080 or the 15n20, they just don't require it. 52100 also benefits from cryo after quench in order to convert retained austenite to martensite. Being a hypereutectoid steel, it's got a lot more carbon to deal with as well as some of the alloying to make carbides. Again though, the cryo won't negatively affect the 1080 or the 15n20, they just don't usually require it.
So long as you can do some homework to find what tempering temps work out for your application (which you'd have to do with any steel) I think it would be just fine.
-d