Lance, I respect your opinion, but respectfully disagree. I am of the opinion that any lock which operates from side to side is, by design, handed. If the compression lock did not favor one hand over the other, at least slightly, there would be no reason that the Gunting was the only model to have it mounted on the opposite side. The Gunting and the Centofante Vesuvius, which came out around the same time, were the first two Spydercos to use the compression lock. Right handed users complained about the Gunting, so every compression lock model since has used the lock orientation used on the Vesuvius.
We could argue the significance of that from now until hell freezes over, and it would not change my opinion. If it wasn't for negative effect I'm sure it would have on sales, I'd challenge Spyderco to orient the compression lock on the Sage 5 like that of the Gunting. Then we'd see whether right handed users felt it was or wasn't "wrong handed".
I can see a left handed person "adapting and overcoming" when there's no choice. But if a truly hand-neutral version a knife is available, why not support it rather than "making do" as we often have to?