Hi, Chris.
A very old knifemaker once told me that "It's the blade that makes it a knife, but the handle sells it."
A good point, for sure, but it's not that simple. You might consider your market, that is who you are planning to sell the knife to, what it is going to be used for, and what price range you intend. Stabilized laminates can be attractive and very sturdy, and some clients are very fond of them. Every knife is different.
I've been making for 24 years, it is my livelyhood, and I can tell you from experience there are no rules but one: every knife that leaves your shop has your name on it, and you had better have a good fit, good finish, nice balance, clean grinds, and stable design. It's more about workmanship than materials in that light.
I still make knives without handle scales at all, that is, skeletonized, bead blasted military combat models that have seen service in Iraq and Afganistan. These guys can't afford my pricier gemstone handles, but they get the same fine steel, excellent grind, and my name and lifetime guarantee.
Don't disregard any handle material, it's about craftsmanship first.
Just my opinion,
Jay