Buffalo horn is very tough and durable which are positives for a hard working handle.
On the other hand though the shock absorption is a little worse than wood and it can be a bit slippery when wet. Roughing it up with sandpaper helps a lot in this regard. It can face issues with shrinking or warping worse than wood, however with regular oiling and care this issue is lessened greatly.
If you check out Joshua Carr's instagram you'll see his 15" horn panawal has held up just fine after a lot of hard use.
https://www.instagram.com/pathseeker84/