Don't quote me on this but I read somewhere that the lock supposed to do it's job without interference form the grip, or at least to be minimal...
As one gentleman mentioned earlier in the thread - Bob Terzuola's, Emerson's, MOD, most of those knives are liner locks.
Makes sense to me. I personally prefer liner locks but have no problem compromising with frame lock if it's done well or if my priority is blade shape for instance.
Unfortunately vast majority of the frame locks, even in well positioned companies, are done so either it's hard to open the blade if your grip falls on the lock,
or the cut-off is exactly where the clip goes over your pocket and it drags your pants up when drown instead of releasing the knife.
These are of course exceptions and I don't want to make rule out of it but it's a fact in my case. I don't own really high end folders with frame locks but had a chance to play with few and
some of those don't make exception either... Another company had the clip positioned directly over the lock bar making opening of the blade with the thumbstud impossible... I still have this knife but not using it at all.
lots of people are looking at the lock as some mechanism that must withstand enormous pressure but this is not the case if you think about it. Liner lock IMO is utilitarian profile lock,
whether the frame lock is done for other reasons. To me these are trendy models before they are truly functional, of course again, with few exceptions. Most of the frame locks are flippers, this makes the knife less complicated for manufacturing,
also somebody brought it up here...
Either way, I have no problem with frame locks, especially if the knife in question looks good, but prefer liner locks.
If one is looking for concrete solid lock, we got CS's back/triad locks, one for stabbing I'd pick Benchmade's AXIS lock before anything else...