I enjoy shooting at 25 yds with a 22 rifle. The problem is it gets a bit unchalleging after a while at that distance. Shooting Necco wafers and animal crackers at that range is still fun as well as general plinking. 50 yds is the usual distance I shoot 22 rifles and at that distance you see the accuracy/precision differences better between rifles and ammo. At 25 yds, I can see the holes without a lot of effort, the walk to the target to change things out is quick, and a sight in at this distance is good longer distances trajectory-wise. I was never much for high magnification over 9x with 22 rifles, but I have a Mueller APV 4.5-14x AO on my CZ 452.
I can't do the "one hole" thing with open sights at 25 yds as a rule with any consistency. I have kept a Mauser 34A (military trainer), and CZ 452 Trainer with open sights for the iron sight challenge. Bought that CZ specifically for the factory irons as they are just about the best factory irons available on a regular production rifle. My preferred rimfire scopes are the Weaver 2.5-7x and 3-9x AO rimfire scope. Years ago, I would only mount 4x scopes on 22 rifles. I believed if you couldn't see the target well enough with the 4x magnification, you probably shouldn't be taking the shot. I've changed in that regard. But it's mostly a target shooting/plinking thing for me versus hunting with 22 rifles any more.
I've never owned a Nylon 66 or any of the Remington Nylon's. Always wanted the lever action 76 Model, but not enough to pay the asking prices these days for them. I never asked, but are you shooting the Nylon 66 with open sights?