First thing to do is to determine what the problem is. I'd suggest putting a dot of magic marker on the screw head, gripping the stop pin with your pliers, and attempting to turn the screw.
If the screw will not turn then thread locker is the culprit and heat would be the cure.
If it feels like the screw is turning, but the dot stays in the same place, then the torx head is stripped. Plumbers tape around the tip of the driver, or crazy gluing the driver in the head sometimes work. If not, then slotting the screw head and using a conventional screwdriver would be the only option.
If the screw is turning, but not coming out, then the thread are stripped. Crazy gluing the driver in place, then gently pulling outward as you turn it may do the trick.
If none of those work, and you're in the USA, returning the knife to Spyderco for repair would be the best option.