It shouldn't take more than a screwdriver to remove a screw in a folder. If a screw is especially tight then it is probably loaded with Loctite. Never try to force a screw out, you don't want to strip the head (some screws are very soft and will strip easily). If a screw doesn't want to come out using a driver and moderate effort, use a soldering iron to soften the Loctite, and then try turning the screw.
Apply the tip of the soldering iron into the head of the screw, apply heat for around 10-15 seconds, then remove the tip and try to turn the screw with a driver before it cools. If it doesn't work, repeat and apply the heat a few seconds longer until it does work.
If that doesn't work, then the screw is probably cross-threaded. And that's a whole different issue.
Many years ago, I stripped a screw on one of my first folders held together with screws (Benchmade). The screws were secured with red Loctite. Ever since then, anytime I remove a screw form a knife for the first time I always use a soldering iron. Always. And I've never stripped a screw since in the dozens of knives I've disassembled.
Taking the time to apply a little heat is a lot easier, a lot faster, and a lot less aggravating than trying to remove a screw with a stripped out head.