That's not really a choice I want to make.Lol. Typically I carry at least one of each, sometimes more, along with other dedicated blades. I believe that they each have numerous advantages.
In my experience, pliers based multitools have more tools and options, as well as being more customizable. Plus they are up to more heavy duty tasks, in most cases. The obvious advantage being the pliers, but I also consider the one handed blades a big advantage. Yes Victorinox offers some 111mm options with one handed opening, but they are not near as smooth and the blade steel is very limited. Bit drivers and inline drivers are far more common. Diamond files are a huge plus.
However, the Vic Saks, the only Saks imo since Wenger is no more , are more compact and ergonomic. I'm no weight weeny, but the lightness appeals to some. The toothpick, tweezers and pin are a big advantage. The ink pen would be more of an advantage if it were more common, but it's not. So I bought a Fisher Space Bullet. Problem solved.
I think probably my favorite models, respectively, are the Leatherman Charge Ti(highly modded/customized) and the Victorinox Trekker. Black two handed, plain edge version.
Picking one would be very difficult and based on situation. But I guess in most cases, the Leatherman would win out.