As said, it depends on the powder and alloy in question. I've tempered some 1095 blades at 325 F, and most powder coats cure right at or above that, so for that 1095 recipe, it could soften the blade. Most blade steels are tempered at temperatures higher than that, 400 F minimum. I used Brownells spray on powder coating to cover a Cold Steel scalping knife, the Carbon V version from years ago. The recommended temperatures were in the 350 F range for half an hour or so. I dont believe I did anything to the blade, since it was most likely tempered above that. A tip in case you dont already know. Sandblasting is a must if you use the Brownells, and I imagine any other bake on coating. Roughing it up on a coarse belt doesnt even come close to the grip sandblasting will give you on the coating. Blasting with coarse playground sand will do the trick. Bead blasting may work, but I've not tried it. It seems a little too fine, but maybe someone has tried and gotten good results.