I don't want to come across as a spyderco fanboy, but the manix2 will probably turn you into one..
Maybe sad for me to say, but practice helps here. I can MFF my Natives, Enduras, Delicas, Caly 3, Tasman and Stretch with no problems (and no wrist). The DF2 and Meercat is possible, but not easy.Yeah, the backlocks are so much harder to middle finger flick. It's possible, but with a lot of wrist flicking, compared to the other locks.