I just happen to have in my hand the very latest study derived from nationwide police records concerning 'one shot stops.' These are actual shootings that occurred here and there with detailed info as to weapons, cartridges, etc.
My SO captain partner provided the study. We were both surprised by some of the latest results. For years, the 357 mag has been Nr One, and the 45 ACP Nr Two. The 357 remains Nr One but here are more of the latest figures. As always, the accuracy of the shooter is paramount. A HP 230 grain 45 tearing out a heart and lungs might not be as quick a stop as a 22 LR to the bridge of the nose. A recent FBI study of one shot stops states that only three types of hits virtually guarantee a stop: To the head that destroys the brain; to the neck that severs the spine; and a large caliber directly to the heart that destroys that critical organ. Although a heart shot does not always instantly incapacitate an attacker while brain and spine shots do.
Anyway:
357 mag: 727 shootings, one shot stop percentage 96%.
45 ACP: 85 shootings, one shot stop percentage (average) 76%.
40 S&W: 58 shootings, one shot stop percentage 95%.
9MM: 141 shootings, one shot stop percentage 90%.
And just for comparison:
22 LR: 1007 shootings, one shot stop percentage (average) 32%.
Shotguns, 12 gauge:
OO buckshot: 528 shootings, one shot stop percentage (average) 91%.
#4 buckshot: 337 shootings, one shot stop percentage 82%.
Slugs: 197 shootings, one shot stop percentage 98%.
Rifles:
223, 23 shootings, one shot stop percentage 100%.
308, 218 shootings, one shot stop percentage 100%.
Gee, I wonder how my BFR 45-70 handguns would do....? Bottom line, the 40 S&W is a wicked cartridge! Also a hell of a lot easier to shoot for many folks than 357s or 45s. Also, don't 'poo-poo' the 'little' nine mm.