Hi, Run2Christ:
As a woman, I can say that I love to carry the Manix 2. I do so, regularly. However, having said that... please take her to a local store and let her handle knives to find what fits best for her. We all know that a knife is an incredibly personal choice. It's like buying a firearm in that it needs to feel just right in our hand. If she isn't comfortable with it, she won't carry it. If she isn't comfortable with it, she'll struggle to build the muscle memory to use it well and safely.
If a local store (or a gun show - lots of knives there usually) isn't an option then let her handle the various knives that you own. There's more to it than just size (both size of knife and size of her hands). She's going to have a preference for material and weight too.
I have smaller hands but the knives I carry would never reflect that. I regularly carry a Manix 2 but I also regularly carry a Manix 2 XL, a Yojimbo 2, a Military Model, a Chinook 2... I could go on but I think you get the idea. And please, and I say this as a woman, please don't suggest that she carry it in her purse. A purse is a black hole and if a time comes that she really needs her knife she won't be able to find it. Carrying a knife on our person can be challenging - it's true if we have pockets they aren't really pockets - but we can adapt and often do with a little creativity.
She's going to love the fact that you are so invested in finding her the right knife for her! She's lucky to have you. Good luck in your search!
Kristi