Professional Big Game hunter W. D. M .Bell, was a turn of the century (1900) advocate of proper shot placement and used a .22 Savage High Power (similar to a 223) to take down 23 African Forest Buffalo.
I Hunted with an old Mainer here in Ct. that shot a lot of deer with an old .22 Savage H.P. . Deadly accurate. Both the rifle and the old Mainer.--KV
He was also known to have taken over 1,000 African Elephants for their Ivory, and liked to use relatively light guns.
You can read about him here:
https://en.wikipedia.org/wiki/W._D._M._Bell
Peter Chapstick also reported an incident in one of his books (perhaps Death in The Long Grass?)where a bird hunter had inadvertently killed several African Elephants with a single .22LR round. The bird hunter had taken a shot at a bird in a tree and had hit an elephant on a hill in the background. The elephant dropped suddenly, either from shock, or from a lucky arterial hit, and fell down the hill, knocking other elephants down along the way and leaving several more dead elephants.
n2s